Everything BioQ can search

Fetch any unreviewed UniProt entry by accession (a first lookup can take about a minute), or count how many proteins an organism has.

Paste a protein sequence and find similar reviewed proteins, with E-values and percent identity.

Retrieve any MGnify protein (MGYP ID) and its sequence, including ones outside the clustered representatives.

Look up representative metagenomic proteins by ID; a miss falls through to the full MGnify set instead of reporting absence.

Ask how many protein clusters were found in soil, the human gut or any other biome, including its sub-biomes.

Find protein clusters that occur in the same metagenome assemblies as a cluster of interest, with their habitats.

See which genes sit next to a metagenomic protein on its contig, with coordinates, strand and gap sizes.

List the Pfam domains of a metagenomic protein, or every protein that carries a given domain such as PF00078.

Find large protein families with no known domain, filter by biome and size, and see the annotated families they co-occur with.

Get the method, resolution, title and sequence of any PDB entry by its four-character code.

Check whether a Swiss-Prot protein has an AlphaFold model and how confident the prediction is.

List measured IC50, Ki, Kd or EC50 values for a target gene or a drug, with unit classes kept apart and the assay type on every row.

Find activity values of approved drugs against a target, side by side with ChEMBL and GtoPdb.

See expert-curated affinities for receptors, ion channels and enzymes by gene or ligand.

List the variants in a gene or genomic window, filter to pathogenic ones, and see review status; uncertain variants are never promoted.

List known and predicted interaction partners of a protein with STRING's combined score, by protein name or, for human, UniProt accession.

Find experimentally reported physical and genetic interactions for a gene, with the experimental system and PubMed ID.

Ask which cancer lineages depend on a gene, or which genes a lineage depends on, with mutation context.

Compare a gene's expression or copy number across cancer cell lines and lineages.

Read the exact DNA sequence of any human region, for example chr11:1000000-1000100.

Read any region of an archaeal, fungal, protist, mitochondrial or viral RefSeq sequence by accession and coordinates.

Read the DNA sequence of any mouse genomic region.

Ask how sensitive cancer cell lines are to a drug (ln IC50 in uM, AUC), per GDSC dataset.

Check whether an exact protein sequence is already present among MGnify representatives.

Find homologs of a protein across bacteria, archaea, plants, fungi and animals, beyond Swiss-Prot.

Search a protein sequence against all of UniProt at 90% redundancy.

Adds ChEMBL binding values reported in ug/mL (converted with each compound's molecular weight) and rows ChEMBL flags as non-standard.

List every target a ChEMBL molecule has activity against, or every molecule tested on a target.

Translate Pfam domain hits into InterPro entries and their descriptions.

Return the full list of cluster IDs found in a biome, not just a sample.

Find remote homologs that alignment search misses, by embedding similarity.

Find the cancer cell lines whose expression profile is closest to a given line.